Cannabis Genetic Response Tool

Important — Please Read

This tool displays your genotypes at specific genetic variants that have been studied in research. It does not predict your individual risk of psychosis or schizophrenia. The science is still evolving, effect sizes are modest, and genetics is just one factor among many. This is for educational purposes only — not medical advice.

Your Results Summary

Below are your genotypes at variants that have been studied in published research. Evidence quality varies — we've labeled each variant to help you understand how robust the findings are.

Putting This In Context

What This Doesn't Tell You

Your actual probability of developing psychosis
Whether cannabis is "safe" or "unsafe" for you
How different products, doses, or frequencies might affect you

Non-Genetic Risk Factors (Often More Important)

Family history — First-degree relative with schizophrenia/psychosis is a major risk factor
Age of first use — Adolescent use (especially before 15) carries higher risk
Frequency & potency — Daily use of high-THC products increases risk substantially
Personal history — Previous psychotic symptoms, even brief ones
Childhood trauma — Associated with increased vulnerability

How To Interpret Gene-Environment Research

Most of these genetic variants only show effects in people who use cannabis frequently (daily or near-daily). Studies generally don't find the same associations with occasional use. The "risk alleles" don't cause psychosis on their own — they may increase vulnerability in the context of heavy use.

Key Research Papers

This list is auto-generated from the studies referenced in the SNP database (plus a small set of featured background papers).